Verification of the expression of a fourth water channel AQP3 in the lens

N Francis - 2022 - researchspace.auckland.ac.nz
… , the membrane permeability to water is mediated by the aquaporin (AQP) family of water …
through embryonic development and postnatal growth in the mouse lens. I found that in the …

[HTML][HTML] Aquaporins have regional functions in development of refractive index in the zebrafish eye lens

K Wang, I Vorontsova, M Hoshino… - … & Visual Science, 2021 - jov.arvojournals.org
… Zebrafish Aqp0a, but not Aqp0b, requires water transport function to maintain embryonic
lens transparency, 24 which in turn impacts the concentration gradients of crystallin proteins. …

[HTML][HTML] Beyond the channels: adhesion functions of aquaporin 0 and connexin 50 in lens development

Z Li, Y Quan, S Gu, JX Jiang - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
expression is detected at E17.5 in lens anterior epithelial cells at a low level and increases at
postnatal day 6.5 when the lens … at the later stages of embryonic development (Varadaraj et …

[HTML][HTML] Physiological mechanisms regulating lens transport

AA Giannone, L Li, C Sellitto, TW White - Frontiers in physiology, 2021 - frontiersin.org
… The distribution and type of aquaporin channels varies in each region of the lens, and these
… drive water through adjacent cells in the lens, aquaporin permeability likely plays a role in …

AQP5 regulates vimentin expression via miR-124–3p. 1 to protect lens transparency

S Tang, G Di, S Hu, Y Liu, Y Dai, P Chen - Experimental Eye Research, 2021 - Elsevier
Aquaporin 5 (AQP5) represents an essential membrane water channel. In the … a mouse
model of AQP5 knockout (KO) using the CRISPR/Cas9 technology, we observed that the lens of …

Deletion of beaded filament proteins or the C-terminal end of Aquaporin 0 causes analogous abnormal distortion aberrations in mouse lens

K Varadaraj, PG FitzGerald, SS Kumari - Experimental eye research, 2021 - Elsevier
Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus
of the water channel protein Aquaporin 0 (AQP0). Previously we have reported that a C-…

[HTML][HTML] Biochemical and biomechanical characteristics of dystrophin-deficient mdx3cv mouse lens

S Karnam, NP Skiba, PV Rao - … et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Embryonic, neonatal, and postnatal mouse eyes were fixed for … in expression of fiber abundant
proteins including crystallins, aquaporin-0 and connexins in P21 lens relative to P2 lenses

Regulation of water flow in the ocular lens: new roles for aquaporins

PJ Donaldson, RS Petrova, N Nair… - The Journal of …, 2023 - Wiley Online Library
lens. Here we focus on the roles played by the aquaporin family of water channels in mediating
lens water fluxes, with a specific focus on AQP5 as a regulated water channel in the lens. …

The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens

Z Liu, S Huang, Y Zheng, T Zhou, L Hu, L Xiong… - Progress in retinal and …, 2023 - Elsevier
… factors influencing differentiation from LECs into lens fibers to form the lens during embryonic
development, how mature LECs function to maintain lens transparency, and changes in …

Aquaporin-5 Dynamic Regulation

C D'Agostino, D Parisis, C Chivasso… - International journal of …, 2023 - mdpi.com
… human lens epithelial cells decreased AQP5 expression and increased vimentin expression
… Aqp5 expression at embryonic day 15 (E15) [123]. Therefore, the downregulation of TET2 …